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KMID : 0380020070220020073
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Korean Journal of Biotechnology and Bioengineering
2007 Volume.22 No. 2 p.73 ~ p.77
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Ulva Lactuca Fucoidan Extract and its Protective Effects on CCl4-induced Liver Dysfunction
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Nam Chun-Suk
Ha Bae-Jin
Kang Kum-Suk
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Abstract
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The effects of Fucoidan extracted from Ulva lactuca on carbon tetrachloride (CCl4)-induced dysfunction in CCl4-posttreated rats were investigated. Ulva lactuca fucoidan (ULF) of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1 ml/kg for 14 days. On the day 15, 3.3 ml/kg of CCl4 dissolved in olive oil (1 : 1) was injected 12 hours before anesthetization. We examined the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) in serum of rats, superoxide dismutase (SOD) in mitochondrial fraction and catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA) in liver of rats. SOD, CAT, GPx decreased, and GOT, GPT, MDA increased in the CCl4-treated group. But SOD, CAT, GPx increased, and GOP, GPT, MDA decreased in the ULF and CCl4-treated group. These results showed that ULF had the protective effects on the liver dysfunction of CCl4-treated rats.
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KEYWORD
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Ulva Lactuca, fucoidan, Liver dysfunction, carbon tetrachloride
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